Research Advance of Autophagy in Acute Intestinal Graft-Versus-Host Disease--Review.
10.19746/j.cnki.issn.1009-2137.2021.03.055
- Author:
Yan-Yu ZHANG
1
;
Ling-Xiao ZHANG
1
;
Xing CUI
2
,
3
Author Information
1. College of Chinese Medicine , Shandong University of Traditional Chinese Medicine; Jinan 250011, Shandong Province, China.
2. College of Chinese Medicine , Shandong University of Traditional Chinese Medicine; Jinan 250011, Shandong Province, China,E-mail: cdz45@
3. com.
- Publication Type:Journal Article
- MeSH:
Autophagy;
Graft vs Host Disease;
Humans;
Immune Tolerance;
Oxidative Stress;
Signal Transduction
- From:
Journal of Experimental Hematology
2021;29(3):998-1001
- CountryChina
- Language:Chinese
-
Abstract:
Acute intestinal graft-versus-host disease is a refractory disease which can affect implantation and become a threat to life in severe cases. Autophagy is an intracellular degradation pathway necessary for maintaining cellular energy homeostasis. In recent years, a large number of studies have found that it is closely related to the pathogenesis and process of acute intestinal graft-versus-host disease. The main mechanisms may involve that inflammatory factor storm after pretreatment and infusion of donor cells induces disordered intestinal immune tolerance, and abnormal oxidative stress damages intestinal mucosal barrier, leading to intestinal rejection of acute graft-versus-host disease via mTOR signal pathway of autophagy, disordered mitophagy and other related pathways.
