β-Thalassemia among Newborns in Wuhan Region and Its Influence Factors.
10.19746/j.cnki.issn.1009-2137.2021.01.031
- Author:
Bin ZHOU
1
;
Qian XIONG
1
;
Wen-Qian CAI
1
;
Xi-Jiang HU
2
;
Shan-Shan SHEN
1
Author Information
1. Wuhan Children's Hospital（Wuhan Maternal and Child Healthcare Hospital）, Tongji Medical College, Huazhong University of Science & Technology，Wuhan 430016，Hubei Province, China.
2. Wuhan Children's Hospital（Wuhan Maternal and Child Healthcare Hospital）, Tongji Medical College, Huazhong University of Science & Technology，Wuhan 430016，Hubei Province, China,E-mail:hxjhyn2008@sina.com.
- Publication Type:Journal Article
- MeSH:
Electrophoresis, Capillary;
Humans;
Infant, Newborn;
Mass Screening;
Mutation;
Thalassemia;
beta-Thalassemia/genetics*
- From:
Journal of Experimental Hematology
2021;29(1):198-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the screening of β-thalassemia among newborns in Wuhan region, so as to explore the influencing factors of Hb A in dried blood spot.
METHODS:Concentrations of Hb A,Hb A2,Hb F in the dried blood spots collected from 99 275 neonates in Wuhan region were analyzed by Sebia capillary electrophoresis. The screening result of β-thalassemia was interpretated accroding to the ratio of each group, the suspicious β-thalassemia newborns were recalled and the gene of thalassemia in those newborns was checked.
RESULTS:Among 99 275 newborns, 1 408 positive patients were found, and the positive rate of screening was 1.41%. A total of 350 patients with gene mutation were found among 709 β-thalassemia suspicious patients. There were significantly statistical differences of positive predictive value among Hb A levels in different groups and there were also significantly statistical differences of positive predictive values among gestational weeks in different groups. No significantly statistical differences were observed among different genetic defects and phenotypes of heterozygous β-thalassemia in Hb A concentrations. Postnatal day and gestational age were significantly and positively associated with Hb A concentrations.
CONCLUSION:The capillary electrophoresis is an effective screening method for β-thalassemia of full-term neonate. Postnatal day and gestational age is associated with the pencentage of Hb A.
