Effects of Tripterine on Adhesion Molecules and Cell Cycle in Human Acute Promyelocytic Leukemia Model Mice.
10.19746/j.cnki.issn.1009-2137.2021.01.012
- Author:
Deng-Peng SONG
1
;
Sheng-Ying WU
2
,
3
Author Information
1. Department of Pharmacy, Taihe Hospital,Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
2. Basic Medical College, Hubei University of Medicine, Shiyan 442000, Hubei Province, China,E-mail: job13872797666@
3. com.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Cycle;
Cell Division;
Humans;
Intercellular Adhesion Molecule-1;
Leukemia, Promyelocytic, Acute/drug therapy*;
Mice;
Mice, SCID;
Triterpenes;
Vascular Cell Adhesion Molecule-1
- From:
Journal of Experimental Hematology
2021;29(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of tripterine on adhesion molecules and cell biological characteristics in mice with acute promyelocytic leukemia (APL) tumor.
METHODS:Eighteen SCID beige mice were caudal vein injected with NB4 cell lines (5×10
RESULTS:The neutrophil decrased and promyelocytes, NB4 cells, B lymphocytes and white blood cells increased in tumor-bearing group as compared with control group (P<0.05), and the expressions of serum P-selectin (P-selectin), soluble vascular adhesion molecule-1 (soluble vascular adhesion molecule-1, sVCAM-1) and soluble intercellular adhesion molecule-1 (soluble intercellular adhesion molecule-1, sICAM-1) all increased (P<0.05). The cell cycle showed that the proportion of G
CONCLUSION:Tripterine may not only inhibit the expression of sVCAM-1 and sICAM-1 proteins in APL tumor-bearing mice and reduce the adhesion of tumor cells, but also block tumor cells at G
