Identification of Volatile Organic Compounds Used to Diagnose and Evaluate Acute Promyelocyte Leukemia.
10.19746/j.cnki.issn.1009-2137.2020.06.010
- Author:
Hong-Xia TANG
1
;
Zhi-Qiang LIU
1
;
Ji-Fei DAI
2
;
Yan LU
3
;
Hai-Long XIA
4
Author Information
1. Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China.
2. Department of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China.
3. Medical Physics and Technology Center, Hefei Academy of Physical Sciences, Chinese Academy of Sciences，Hefei 230031, Anhui Province, China.
4. Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China，Department of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China,E-mail: 1245149378@qq.com.
- Publication Type:Journal Article
- MeSH:
Exhalation;
Gas Chromatography-Mass Spectrometry;
Granulocyte Precursor Cells;
Humans;
Leukemia, Promyelocytic, Acute/diagnosis*;
Volatile Organic Compounds/analysis*
- From:
Journal of Experimental Hematology
2020;28(6):1848-1852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the characteristics of volatile organic compounds (VOCs) in expiratory air components of patients with acute promyelocytic leukemia (APL), and assess the feasibility of VOCs for the diagnosis and prognostic evaluation of APL.
METHODS:The VOCs exhaled from the patients with APL and healthy volunteers should be analyzed with SPME-GC/MS, and compared between newly-diagnosed group, relapse group, remission group, and healthy group with Wilcoxon/Kruskal-Wallis one-way analysis of variance and Dunn-Bonferroni test.
RESULTS:Dimethyl sulfide, toluene, and dodecane obtained of newly-diagnosed APL patients were significantly higher, while ethanol, n-hexanal, and benzaldehyde were significantly lower than those of healthy people (P<0.05). Compared with the newly-diagnosed group, dimethylsulfide, toluene, and dodecane of the remission group significantly decreased, while ethanol, n-hexanal, and benzaldehyde significantly increased (P<0.05), which was just opposite from the relapse group.
CONCLUSION:Dimethyl sulfide, toluene, dodecane, ethanol, n-hexanal, and benzaldehyde can be used as biomarkers for the diagnosis and prognosis assessment of APL patients.
