Effect of the Risk Factors for Treatment-Related Death in Children with Acute Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2020.06.008
- Author:
Ping ZHOU
1
;
Hao XIONG
2
;
Jian-Xin LI
1
;
Hui LI
1
;
Fang TAO
1
;
Zhuo WANG
1
;
Zhi CHEN
1
;
Kai-Li LI
1
;
Sha WU
1
Author Information
1. Department of Hematology and Oncology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital)， Tongji Medical College， Huazhong University of Science & Technology, Wuhan 430016, Hubei Province, China.
2. Department of Hematology and Oncology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital)， Tongji Medical College， Huazhong University of Science & Technology, Wuhan 430016, Hubei Province, China,E-mail:22587481@qq.com.
- Publication Type:Journal Article
- MeSH:
Child;
Child, Preschool;
Death;
Female;
Humans;
Infant;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis;
Retrospective Studies;
Risk Factors
- From:
Journal of Experimental Hematology
2020;28(6):1837-1841
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the possible risk factors of death in children with acute lymphoblastic leukemia (ALL) after treatment.
METHODS:The clinical data of 31 children with newly diagnosed acute lymphoblastic leukemia and dead after treatment in the Hematology Oncology Department of Wuhan children's Hospital from January 1, 2016 to December 31, 2019 were retrospectively analyzed. Univariate factor analysis and multivariate Cox regression analysis were used to analyze the each indexes of ALL children, and the possible risk factors causes of death in ALL children after treatment were analyzed.
RESULTS:Among 230 newly diagnosed ALL children, 31 (13.4%) cases were dead. Among them, there were 12 male and 19 female. The mortality rates were 9%(12/133) for male and 19.5%(19/97) for female, which showed a significantly difference（P=0.02）； among the dead ALL children, 6 were less than 1 year old, 23 were 1-10 years old, and 2 was more than 10 years old. The mortality rates in different age groups were 46.1 % (6/13), 11.7%(23/195) and 9%(2/22), respectively, which showed a significantly difference（P=0.00）； the mortality rates of the ALL children in standard risk group, medium risk group and high risk group were 6.7% (4/59), 11.9% (13/10
CONCLUSION:The female, less than 1 year old at initial diagnosis, high risk ALL, WBC>50×10
