Risk factors for neutropenia of late newborns.
- Author:
Li LI
1
;
Bo YANG
1
;
Xiang-Yu GAO
1
;
Yi REN
1
;
Min SU
1
;
Chun-Yan YANG
1
;
Di HUANG
1
;
Hui-Ying WANG
1
Author Information
1. Department of Neonatology, Xuzhou Central Hospital/Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu 221009, China.
- Publication Type:Journal Article
- MeSH:
Granulocyte Colony-Stimulating Factor;
Humans;
Infant;
Infant, Newborn;
Infant, Premature;
Leukocyte Count;
Neutropenia;
Risk Factors;
Sepsis
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(4):375-380
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the risk factors and treatment for neutropenia of late newborns (NLN).
METHODS:Related clinical data were collected from the preterm infants and critically ill neonates who were admitted to the neonatal intensive care unit from July 2019 to January 2020. A total of 46 newborns with a blood absolute neutrophil count (ANC) of < 1.5×10
RESULTS:Among the 46 neonates in the NLN group, 29 had a gestational age of < 32 weeks, 14 had a gestational age of 32-37 weeks, and 3 had a gestational age of > 37 weeks. There was no significant difference between the two groups in the incidence rates of gestational hypertension, premature rupture of membranes > 18 hours and intrauterine distress, 5-minute Apgar score, the duration of positive pressure ventilation, the incidence rate of early-onset sepsis, and the type of initially used antibiotics (
CONCLUSIONS:The risk of NLN increases with the presence of late-onset sepsis and the increase in the duration of antibiotic use. NLN is generally a benign process. G-CSF appears to be safe and effective for NLN with severe disease conditions or severe reduction in ANC.
