Clinical effect of an additional maintenance dose of caffeine before ventilator weaning in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial.
- Author:
Ling-Song YAO
1
;
Xin-Zhu LIN
1
;
Jing HUANG
1
;
Li-Xia TANG
1
Author Information
1. Department of Neonatology, Women and Children's Hospital, School of Medcine, Xiamen University/Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, Fujian 361003, China.
- Publication Type:Randomized Controlled Trial
- MeSH:
Caffeine;
Humans;
Infant;
Infant, Newborn;
Infant, Premature;
Maintenance;
Prospective Studies;
Respiratory Distress Syndrome, Newborn/therapy*;
Ventilator Weaning
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(1):31-36
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical effect of an additional maintenance dose (5 mg/kg) of caffeine citrate injection at 1 hour before ventilator weaning in improving the success rate of ventilator weaning in preterm infants (gestational age ≤32 weeks) with respiratory distress syndrome (RDS) on mechanical ventilation.
METHODS:A total of 338 preterm infants with RDS (gestational age of ≤32 weeks) who were admitted to the Neonatal Intensive Care Unit of Xiamen Maternal and Child Health Hospital from January 2017 to December 2019 and treated with mechanical ventilation were enrolled. They were randomly divided into an observation group and a routine group, with 169 infants in each group. Both groups received early routine treatment with caffeine. The infants in the observation group received an additional maintenance dose of caffeine citrate injection at 1 hour before ventilator weaning. The two groups were compared in terms of reintubation rate and number of apnea episodes within 48 hours after ventilator weaning, changes in blood gas parameters, blood glucose, heart rate, and mean blood pressure at 2 hours after ventilator weaning, and incidence rates of major complications during hospitalization.
RESULTS:Compared with the routine group, the observation group had significantly lower reintubation rate (
CONCLUSIONS:An additional maintenance dose of caffeine citrate injection at 1 hour before ventilator weaning is safe and effective in improving the success rate of ventilator weaning in preterm infants with RDS and thus holds promise for clinical application.
