Progress of studies on anti-breast tumor mechanism of alkaloids.
10.19540/j.cnki.cjcmm.20201015.601
- Author:
Pan ZHANG
1
;
Yi-Fan ZHANG
2
;
Qun-Li CHEN
2
;
Wang-Chun DU
2
;
Hong YAO
2
;
Mei ZHAO
3
Author Information
1. Graduate School, Shanghai University of Chinese Medicine Shanghai 201203, China.
2. Department of Pharmacy, Shanghai University of Medicine & Health Sciences Shanghai 201318, China.
3. Department of Pharmacy, Shanghai University of Medicine & Health Sciences Shanghai 201318, China Graduate School, Shanghai University of Chinese Medicine Shanghai 201203, China.
- Publication Type:Review
- Keywords:
alkaloids;
anti-tumor mechanism;
breast tumor
- MeSH:
Alkaloids/pharmacology*;
Apoptosis;
Autophagy;
Breast Neoplasms/drug therapy*;
Cell Cycle Checkpoints;
Cell Line, Tumor;
Cell Proliferation;
Female;
Humans
- From:
China Journal of Chinese Materia Medica
2021;46(2):312-319
- CountryChina
- Language:Chinese
-
Abstract:
Breast tumor has become one of the malignant tumors with the highest incidence, and is a serious threat to human health, especially to women. Chemotherapy is an important anti-breast tumor therapy, which can be used in almost every stage of breast tumor therapy alone or in the combination with surgery and radiation therapy. Alkaloids are a kind of ubiquitous natural products, and important active components of various medicinal plants. A large number of studies have shown that alkaloids could exert an anti-breast tumor effect by inhibiting proliferation, metastasis and angiogenesis, resisting mitosis, promoting apoptosis and autophagy, and triggering cell cycle arrest. The extensive anti-breast tumor effect makes alkaloids an important candidate drug source. This paper reviews the anti-breast tumor mechanism of natural products of alkaloids.
