Production and quality control of original herbal materials of Danhong Injection.
10.19540/j.cnki.cjcmm.20200915.302
- Author:
Li-Jun HAO
1
;
Ai-Hua LIANG
2
;
Cong-Zhao FAN
3
;
Jing-Yuan SONG
4
Author Information
1. Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
2. Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Materia Medica,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
3. Key Laboratory of Traditional Chinese Medicine and Ethnic Medicine Resources, Xinjiang Institute of Chinese Materia Medica and Ethnical Materia State Administration of Traditional Chinese Medicine Urumqi 830002, China.
4. Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China Engineering Research Center of Chinese Medicine Resource, Ministry of Education Beijing 100193, China.
- Publication Type:Journal Article
- Keywords:
Carthami Flos;
Danhong Injection;
Salviae Miltiorrhizae Radix et Rhizoma;
continuous cropping obstacles;
cultivation;
detection of xenobiotic pollutants;
identification;
quality control
- MeSH:
China;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2020;45(22):5443-5451
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular and cerebrovascular diseases are the leading cause of death for residents in China. Danhong Injection(DHI) decoction piece is prepared from Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos, with the function of promoting the blood circulation, removing the blood stasis, relaxing the sinews and dredging the collaterals. In recent years, about 100 million bottles of DHI have been sold. Consequently, its safety and effectiveness are very important to a large number of patients. Raw materials are the source and foundation for production of traditional Chinese medicine injections. In this article, we reviewed the identification of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos, resource distribution, cultivation, quality control, and detection of xenobiotic pollutants, in order to guide the production of high-quality, stable, and pollution-free raw materials. This will be a benefit in ensuring the safety and effectiveness of DHI and reducing the incidence of adverse reactions from the raw materials. By comparing the similarities and differences between the quality standards of Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos and DHI, we provided some comments for improving the quality standards and post-marketing reevaluation of DHI, and provided some theoretical supports for the production of high-quality herbal raw materials.
