Assessment of Prognostic Factors of Racial Disparities in Testicular Germ Cell Tumor Survival in the United States (1992-2015).

Jing WU; Yi Bing JI; Bi Wei TANG; Matthew BROWN; Bao Hua WANG; Chen Lei DU; Jian Shu DU; Xue Mei WANG; Li Jun CAI; Guo Yi WU; Yan ZHOU

Return

Assessment of Prognostic Factors of Racial Disparities in Testicular Germ Cell Tumor Survival in the United States (1992-2015).

Author: Jing WU ¹ ; Yi Bing JI ¹ ; Bi Wei TANG ² ; Matthew BROWN ³ ; Bao Hua WANG ¹ ; Chen Lei DU ¹ ; Jian Shu DU ² ; Xue Mei WANG ² ; Li Jun CAI ⁴ ; Guo Yi WU ⁵ ; Yan ZHOU ⁶
Author Information

1. National Center for Chronic and Non-communicable Diseases Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
2. Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China.
3. National Cancer Insitiute, National Institutes of Health, Bethesda 20892, Maryland, United States.
4. Shanghai Topgen Biopharm Technology Co.,Ltd, Shanghai 201203, China.
5. Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
6. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China;Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 200000, China.
Publication Type:Journal Article
Keywords: Germ cell tumor; Race; Survival analysis; Survival rate; Testicular cancer
MeSH: Adult; Health Status Disparities; Humans; Male; Neoplasms, Germ Cell and Embryonal/pathology*; Prognosis; Risk Factors; SEER Program/statistics & numerical data*; Seminoma/pathology*; Survival Rate/trends*; Testicular Neoplasms/pathology*; United States/ethnology*
From: Biomedical and Environmental Sciences 2021;34(2):152-162
CountryChina
Language:English
Abstract: Objective:Testicular germ cell tumors (TGCT) are the most common cancer among men aged 15 to 39 years. Previous studies have considered factors related to TGCT survival rate and race/ethnicity, but histological type of the diagnosed cancer has not yet been thoroughly assessed.
Methods:The data came from 42,854 eligible patients from 1992 to 2015 in the Surveillance Epidemiology and End Results 18. Frequencies and column percent by seminoma and nonseminoma subtypes were determined for each covariates. We used Cox proportional hazard regression to assess the impact of multiple factors on post-diagnostic mortality of TGCT.
Results:Black males were diagnosed at a later stage, more commonly with local or distant metastases. The incidence of TGCT in black non-seminoma tumors increased most significantly. The difference in survival rates between different ethnic and histological subtypes, overall survival (OS) in patients with non-seminoma was significantly worse than in patients with seminoma. The most important quantitative predictor of death was the stage at the time of diagnosis, and older diagnostic age is also important factor affecting mortality.
Conclusion:Histological type of testicular germ cell tumor is an important factor in determining the prognosis of testicular cancer in males of different ethnic groups.