The metabolic networks of ferroptosis and links to lung diseases.
- Author:
Hai-Peng CHENG
1
;
Dan-Dan FENG
1
;
Shao-Jie YUE
2
;
Zi-Qiang LUO
3
Author Information
1. Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
2. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410078, China.
3. Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China. luoziqiang@csu.edu.cn.
- Publication Type:Review
- MeSH:
Ferroptosis;
Humans;
Iron;
Lipid Peroxidation;
Metabolic Networks and Pathways;
Pulmonary Disease, Chronic Obstructive
- From:
Acta Physiologica Sinica
2020;72(5):566-574
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a newly discovered non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation. The present studies have shown that many metabolic processes and homeostasis are affected by ferroptosis. It is related to many lung diseases, including acute lung injury, chronic obstructive pulmonary disease and pulmonary fibrosis, etc. Currently, the research on ferroptosis is still in its infancy. Previous studies have confirmed that ferroptosis is regulated by a variety of genes, and the mechanism is complex, mainly involving iron homeostasis and lipid peroxidation metabolism. This review summarizes some regulation networks of metabolic processes associated with ferroptosis and discusses the roles of ferroptosis in the pathophysiological progression of many lung diseases. We expected to provide new ideas and references for the treatment of these diseases.
