Role and damage mechanism of retinal pigment epithelial cells in dry ARMD
10.3980/j.issn.1672-5123.2021.7.14
- VernacularTitle:干性ARMD中视网膜色素上皮细胞的作用及损伤机制
- Author:
Jia-Min Meng
1
Author Information
1. <sup>1</sup>School of Life Science, Northwest University, Xi'an 710069, Shaanxi Province, China|<sup>2</sup>The First Affiliated Hospital of Northwest University;Xi'an First Hospital, Xi'an 710002, Shaanxi Province, China
- Publication Type:Review
- Keywords:
retinal pigment epithelial cells;
dry age-related macular degeneration;
damage mechanism
- From:
International Eye Science
2021;21(7):1200-1204
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(ARMD)is a major cause of irreversible loss of central vision in the elderly. Typical characteristics of ARMD consist of retinal pigment epithelium(RPE), degenerative changes of choroidal capillaries and vitreous warts in macular area. Clinical ARMD is divided into two subtypes: non effusive(dry or atrophic)and effusive(wet or neovascular). The occurrence of the disease is the result of the interaction of many factors, such as age, environment, heredity, smoking, oxidative stress and cardiovascular dysfunction, etc. In view of the important role of RPE cells in pathogenesis of ARMD, the effects and possible mechanisms of blue light, smoking, oxidative stress, lipofuscin accumulation, chronic inflammation and protein homeostasis on the onset of dry ARMD are summarized by focusing on RPE cells. This will provide new ideas to help understand and prevent the occurrence of dry ARMD.
- Full text:202107014.pdf
