Immune mechanism of biliary epithelial cell injury in the small intrahepatic bile ducts in primary biliary cholangitis
10.3969/j.issn.1001-5256.2021.06.051
- VernacularTitle:原发性胆汁性胆管炎肝内小胆管上皮细胞损伤的免疫学机制
- Author:
Yafei YANG
1
;
Zhihua DENG
Author Information
1. Department of Gastroenterology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
Primary Biliary Cholangitis;
Biliary Epithelial Cells;
Cell-Mediated Immunity;
Cytokines
- From:
Journal of Clinical Hepatology
2021;37(6):1466-1468
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease caused by the combined effect of genetic and environmental factors and characterized by the apoptotic necrosis of biliary epithelial cells (BEC) in the small intrahepatic bile ducts. This article describes the effect of B cells, macrophages, natural killer cells, NKT, and T cells on the immune injury of BEC during PBC, so as to provide some guidance for the targeted immune therapy for PBC.
