Detection of chloroprene in human blood by headspace gas chromatography
10.11763/j.issn.2095-2619.2016.06.020
- Author:
Chao-Yang WANG
1
;
Cheng-Ming MENG
1
;
Wen-Hua QIN
1
Author Information
1. Henan Institute of Occupational Health Zhengzhou,Henan 450052,China
- Publication Type:Journal Article
- Keywords:
Chloroprene;
Headspace gas chromatography;
Blood
- From:
China Occupational Medicine
2016;43(06):722-727
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a detection method for chloroprene in human blood by headspace gas chromatography.METHODS: The blood sample was placed directly in the headspace bottle,after the head space automatic sampling,the target object was detected by gas chromatography with electron capture detector,quantified by external standard method.RESULTS: The good linearity range of chloroprene was 0. 00-160. 00 μg / L,and the correlation coefficient was 0. 999 4. The detection limit was 0. 10 μg / L and the minimum detectable concentration in blood samples was 0. 10 μg / L. The with-run relative standard deviation( RSD) was 1. 38%-1. 91%,and the between-run RSD was 2. 11%-3. 08%. The average recovery rate was 89. 00%-93. 88%. CONCLUSION: The method has the features of high sensitivity,wide linear range and simple sample processing,which was suitable for efficient detection for large quantity of samples.
