Comparison of therapeutic effects between comprehensive therapy and routine therapy in treatment of occupational chronic n-hexane poisoning
10.11763/j.issn.2095-2619.2016.06.002
- Author:
Chun-Yue FAN
1
;
Jia-Bin CHEN
1
;
Xiao-Yuan WU
1
;
Yan-Yan WANG
1
;
Han-Lin HUANG
1
;
Li-Hua XIA
1
;
Jia-Wen HUANG
1
;
Xin-Xiang QIU
1
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment;Guangdong Provincial Key Laboratory of Occupational Diseases Prevention and Treatment Guangzhou,Guangdong 510300,China
- Publication Type:Journal Article
- Keywords:
n-Hexane;
Chronic poisoning;
Occupational poisoning;
Comprehensive treatment with traditional Chinese and Western medicine;
Comprehensive therapy;
Routine therapy;
Clinical curative effect
- From:
China Occupational Medicine
2016;43(06):639-644
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the therapeutic effects between comprehensive therapy and routine therapy in treatment of occupational chronic n-hexane poisoning. METHODS: By randomized controlled trial,116 cases with occupational chronic n-hexane poisoning were divided into two groups: the control group( n = 58) and the treatment group( n = 58). Subjects in the control group were given vitamin B_(12) and vitamin B_1 for neural nutrition; and Danshen and deproteinized calf blood extractive injection for activating blood circulation to dissipate blood stasis. Subjects in the treatment group were treated with comprehensive treatment including traditional Chinese and Western medicine,which including mouse nerve growth factor,acupuncture,physical therapy( infraredtherapy,microwave irradiation therapy),Chinese medicine steamingwashing and comprehensive rehabilitation therapy for a period of 12 weeks in addition to the conventional treatment. The curative effect and adverse reactions of both groups were observed after 12 weeks,and the treatment results and hospital stay were followed up. RESULTS: Before treatment,no significant differences( P > 0. 05) were noted in both groups in scores of neurological symptoms,signs,activities of daily living and neurogenic damage indexes of electroneuromyography[including motor digital latency( MDL),motor nerve conduction velocity( MCV),sense nerve conduction velocity( SCV) of median nerve,ulnar nerve,sural nerve or common peroneal nerve; and the detection of lengthen MDL,shorten MCV and SCV]. After treatment,patients in both groups got better in terms of the above indicators( P < 0. 05),with larger extend of improvement noted in the treatment group than in the control group( P < 0. 05). No obvious adverse reactions were noted in the 2 groups. Hospital stay of patients in the treatment group was about 2 months shorter than that in the control group( P < 0. 05). CONCLUSION: The therapeutic effects of comprehensive therapy on occupational chronic n-hexane poisoning are obviously better than routine therapy,which is an effective and safe therapeutic method.
