METHODS: Totally 80 children with allergic conjunctivitis who were admitted to our hospital from May 2016 to June 2018, they were randomly divided into the control group and the observation group, 40 cases in each group. The control group was given pranoprofen eye drops, on the basis of the control group, the observation group was combined with azelastine hydrochloride eye drops for adjuvant treatment. The two groups children were treated continuously for 1wk. The clinical efficacy, the changes of the clinical symptoms, tear film stability, inflammatory factors and adverse reactions were compared between the two groups.

RESULTS: After 1wk of treatment, the clinical efficacy of the observation group was 95.0%, higher than that of the control group, 85.0%(P=0.035); the itching, tearing, foreign body sensation and photophobia scores in the observation group were lower than that of the control group \〖(1.13±0.36)vs (2.28±0.41)scores,(1.05±0.33)vs (2.14±0.49)scores,(1.17±0.46)vs (2.28±0.59)scores(1.29±0.37)vs (1.84±0.55)scores\〗(P<0.05); the tear film rupture time(BUT)in the observation group was significantly higher than that of the control group, and the corneal fluorescein staining test(FL)was significantly lower than that of the control group \〖(11.96±1.14)vs (5.85±0.92)s,(2.85±0.33)vs (6.21±0.68)scores\〗(P<0.05); the tears histamine(HA), eosinophilic cationic protein(ECP)and immunoglobulin E(IgE)in the observation group were lower than that of the control group \〖(31.62±4.51)vs (65.03±6.48)μg/L,(2.20±0.28)vs (7.26±0.72)μg/L,(0.06±0.01)vs (0.18±0.04)mg/L\〗(P<0.05); there was no significant difference in the overall incidence of adverse reactions between the two groups during treatment(χχ2=1.897, P=0.168).

CONCLUSION: The clinical efficacy of azelastine hydrochloride combined with pranoprofen in the treatment of allergic conjunctivitis in children is significant, which can effectively improve the level of inflammatory factors, promote the tear film stability recovery, and have good safety, the clinical value is high.