Research progress of ophthalmic examination in the diagnosis of Alzheimer's disease
10.3980/j.issn.1672-5123.2020.6.18
- VernacularTitle:眼科检查在阿尔茨海默病诊断中的研究进展
- Author:
Han-Yun Wu
1
Author Information
1. Department of Ophthalmology, First Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Ophthalmology; Chongqing Institute of Ophthalmology, Chongqing 400016, China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
ocular manifestation;
biomarker
- From:
International Eye Science
2020;20(6):1007-1010
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a neurological degenerative disease that is insidious onset. The main pathological features are deposition of amyloid β(Aβ)and intracellular hyperphosphorylated tau protein. In recent years, studies have found that the manifestations of AD exist not only in the brain but also in the eyes, such as impaired visual function, changes in the pupil, Aβ deposition in the lens, changes in the retina and choroid, and so on. These ocular manifestations provide clues to the early diagnosis of AD and have positive clinical and social significance. Therefore, this article reviews the ocular manifestations of AD and their use as biomarkers for diagnosis and progression.
- Full text:202006018.pdf
