Research status and progress of miR-15a in ophthalmological diseases
10.3980/j.issn.1672-5123.2020.6.16
- VernacularTitle:miR-15a在眼科疾病中的研究现状及进展
- Author:
Yu-Bo Li
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 157000, Heilongjiang Province, China
- Publication Type:Journal Article
- Keywords:
miR-15a;
ophthalmic diseases;
diabetic retinopathy;
cataract;
retinal vascular endothelial cells;
retinal pigment endothelial cells
- From:
International Eye Science
2020;20(6):999-1002
- CountryChina
- Language:Chinese
-
Abstract:
miRNA-15a(miR-15a)is a non-coding small molecule RNA located on 13q14 gene. It affects the growth, development, differentiation and apoptosis of all organs and cells of the whole body. As the study progressively deepened, it was found that the role of miR-15a in different tissues and cells was not entirely consistent. Sometimes it plays a role in suppressing cancer, and sometimes it promotes cancer. The signal pathways it affects are complex and diverse. With the deepening of biological research into cell signaling pathways, miRNA-15a has become a miRNA more extensively studied. But in the ophthalmology, the corresponding research is not much. In this article, we mainly focus on the mechanism of miR-15a and its current research situation in ophthalmic diseases, so as to provide a reference for further study and their treatment.
- Full text:202006016.pdf
