Advances in study of complement activation and autophagy on age-related macular degeneration
10.3980/j.issn.1672-5123.2020.6.15
- VernacularTitle:补体激活与自噬在年龄相关性黄斑变性中的研究进展
- Author:
Yu-Lu Liu
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210023, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
complement activation;
autophagy
- From:
International Eye Science
2020;20(6):995-998
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration is a macular disease which incidence increases with age. Currently, it is believed that its pathogenic factors are related to patients' age, heredity, smoking, oxidative stress, immune inflammatory response, RPE cell aging and metabolic abnormalities. Complement system plays an important role in the body's defense against infection, immune regulation and inflammatory response. Immune inflammation caused by abnormal activation of complement system is considered to be an important cause of ARMD in recent years. Autophagy also plays a role in ARMD. Normal autophagy is an important way for cells' self-protection and maintenance of homeostasis. When autophagy is blocked, oxidative stress can be aggravated, which will lead to the development of ARMD. The balance regulation between complement activation and autophagy is an important method to control the development of ARMD.
- Full text:202006015.pdf
