Research progress of advanced glycation end products in glaucoma
10.3980/j.issn.1672-5123.2020.6.14
- VernacularTitle:糖基化终末产物在青光眼中的研究进展
- Author:
Ming-Yue Han
1
Author Information
1. 1Department of Ophthalmology; 2Clinical Medical Laboratory, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, Shandong Province, China; 3Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264000, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
advanced glycation end products;
glaucoma;
pathogenesis;
prevention and treatment of glaucoma
- From:
International Eye Science
2020;20(6):990-994
- CountryChina
- Language:Chinese
-
Abstract:
Advanced glycation end products(AGEs)accumulate in various tissues in the body, and induce a series of biological responses by regulating the expression of related factors and activating signal pathways, causing age-related diseases and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Atherosclerosis. Glaucoma, which is the leading cause of vision loss after cataract worldwide, is a degenerative disease of the optic nerve that ultimately leads to irreversible visual field loss. The accumulation of excessive AGE sin the retina and other eye tissues of glaucoma patients activates signal pathways and triggers biological responses, causing damage to the structure and function of tissues and cells, and participating in the pathogenesis of glaucoma. This article mainly describes the latest progress of AGEs in glaucoma pathogenesis, treatment, screening and other related research, and provides new ideas and research methods for the prevention and treatment of glaucoma.
- Full text:202006014.pdf
