Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions
10.16250/j.32.1374.2020069
- VernacularTitle:吲哚胺2, 3-双加氧酶参与调控寄生虫与宿主免疫互作关系的研究进展
- Author:
Li-Jun WANG
1
;
Pei-Yu MA
2
;
Hui LIU
1
;
Jian-Ping CAO
3
;
Hua-Mei LI
3
;
Ming-Hui ZHENG
4
Author Information
1. Department of Parasitology, Zunyi Medical University, Guizhou Key Laboratory of Gene Detection and Treatment, Zunyi 563003, China
2. Institute of Criminal Science and Technology, Jiaozuo Municipal Public Security Bureau, Henan Province, China
3. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, China
4. Department of Parasitology, Zunyi Medical University, Guizhou Key Laboratory of Gene Detection and Treatment, Zunyi 563003, China; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, China
- Publication Type:Journal Article
- Keywords:
Parasite;
Indoleamine 2, 3-dioxygenase;
Immune interaction;
Immune escape
- From:
Chinese Journal of Schistosomiasis Control
2021;33(2):209-212
- CountryChina
- Language:Chinese
-
Abstract:
Indoleamine 2, 3-dioxygenase (IDO) is an important immunoregulatory enzyme, which mediates immune effects by depleting tryptophan and producing multiple metabolites. Recently, the studies on the immune function of IDO have been mostly restricted in tumors and autoimmune diseases. Nevertheless, there are few studies pertaining to the role of IDO in parasitic diseases, notably in parasite-host immune interactions. This review mainly describes IDO-mediated immunoregulatory effects and its regulation of parasite-host interactions, so as to provide insights into the development of immune intervention schemes against parasitic diseases.
