Research progress on roles of autophagy regulating T lymphocyte function in the genesis and development of diseases
DOI：10.3872/j.issn.1007-385x.2021.03.001
- VernacularTitle:自噬调控T淋巴细胞功能在疾病发生发展中作用的研究进展
- Author:
YANG Yi1
1
;
LIU Qinying2
2
;
ZHENG Qiuhong2
2
;
CHEN Li1
1
Author Information
1. Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, Fujian, China
2. Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital & Cancer Hospital Affiliated to Fujian Medical University, Fuzhou 350014, Fujian, China
- Publication Type:Journal Article
- Keywords:
T lymphocyte cell function;
autophagy;
immunity;
antitumor;
disease
- From:
Chinese Journal of Cancer Biotherapy
2021;28(3):215-224
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Autophagy, as an important intracellular metabolic pathway, has been proved to be ubiquitous in many kinds of cells. Its functional impairment can easily cause lots of diseases, such as cancer, leukemia, liver disease, diabetes and heart disease. In particular, autophagy is important for the development, differentiation and regulation of immune function of T lymphocytes. Abnormal autophagy of T lymphocytes can cause immune dysfunction and lead to diseases, such as inflammation, infection and autoimmunity. In view of the important role of autophagy in regulating T lymphocyte function and disease, this article illustrates the research progress on autophagy regulating the homeostasis, survival, proliferation, senescence, metabolism, immune function of T lymphocytes and many diseases, including tumors, in recent years.
- Full text:20210301.pdf
