A new dimeric benzylisoquinoline alkaloid from Corydalis yanhusuo
10.16438/j.0513-4870.2020-1564
- VernacularTitle:醋制延胡索中一个新苄基异喹啉二聚体生物碱
- Author:
Gui-yang XIA
1
;
Biao-bing XIAO
2
;
Ling-yan WANG
2
;
Dong-jie FANG
2
;
Huan XIA
1
;
Sheng LIN
1
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
italic>Corydalis yanhusuo;
imeric alkaloid;
PD-1/PD-L1;
anti-inflammatory
- From:
Acta Pharmaceutica Sinica
2021;56(2):553-556
- CountryChina
- Language:Chinese
-
Abstract:
(±)-Bicoryanhunine B (1), a new dimeric benzylisoquinoline alkaloid was isolated from the dried tubers of Corydalis yanhusuo by various chromatographic methods, including silica gel, Sephadex LH-20, reverse phase C18, and semi-preparative HPLC. Its structure was determined by spectroscopic methods, including UV, IR, ESI-MS, HR-ESI-MS and 1D/2D NMR. (±)-Bicoryanhunine B (1) was a moderate PD-1/PD-L1 interaction inhibitor with an IC50 value of 7.80 ± 0.49 μmol·L-1. In addition, 1 exhibited potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with an IC50 value of 4.83 ± 2.21 μmol·L-1.
