Current status and future of drugs targeting platelets-tumor cells interactions
10.16438/j.0513-4870.2020-1122
- VernacularTitle:靶向血小板与肿瘤细胞相互作用药物的现状和未来
- Author:
Shan LI
1
;
Zi-hao CHEN
1
;
Ming LÜ
2
;
Yan ZHU
1
Author Information
1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Research Institute, Tianjin 300457, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
platelet;
tumor cell;
interaction;
tumor metastasis;
potential drug
- From:
Acta Pharmaceutica Sinica
2021;56(2):360-367
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between platelets and tumor cells can not only promote the metastasis of malignant tumors, but also affect the formation of malignant tumor-related thrombus. When tumor cells enter the blood, they will immediately activate platelets to make them adhere to the surface of tumor cells, protecting tumor cells from blood flow shear force and immune system attack, thereby promoting tumor metastasis. At the same time, the massive adhesion of platelets may also lead to the formation of thrombus. In this article, we use the methods of ingenuity pathway analysis and literature integration to explore the mechanism of platelet-tumor cell interaction and potential drugs for the treatment of malignant tumor metastasis based on the platelet-tumor cell interaction. It provides a certain theoretical basis and clinical reference for the future development of new drugs targeting platelet-tumor cell interaction based on its mechanism of action.
