Naphthoquinones from Rhinacanthus nasutus and Their Pharmacological Activities
10.13422/j.cnki.syfjx.20200712
- VernacularTitle:壮族药白鹤灵芝萘醌类化学成分及其药理作用研究进展
- Author:
Tian-xiu MENG
1
;
Li-long YANG
2
;
Zhi-qiang GONG
1
;
Fang LIANG
1
;
Wen-jun TANG
1
Author Information
1. Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning 530222, China
2. First Affiliated Hospital of Guangxi of University of Traditional Chinese Medicine, Nanning 530023, China
- Publication Type:Research Article
- Keywords:
Rhinacanthus nasutus;
naphthoquinones;
pharmacological activities;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(10):213-219
- CountryChina
- Language:Chinese
-
Abstract:
Rhinacanthus nasutus is the shrubs of Acanthacesa of Rhinacanthus nasutus. It has been used as traditional Zhuang medicine for thousands of years, with antipyretic and alexipharmic, antibacterial and anti-inflammatory, antiasthmatic and expectorant effects. Modern pharmacological studies have shown that R. nasutus has been used for treatment of various diseases, including pneumonia, gastritis and hepatitis. In addition, naphthoquinone esters isolated from this plant exhibits antitumor, antiviral, antifungal, and immunomodulatory activities, with a high application value. Scholars at home and abroad have isolated a variety of compounds from R. nasutus, including 20 naphthoquinones, organic acids, lignans, alkaloids and other structural types of components. Among them, naphthoquinones have a variety of biological activities. Up to now, there are no systematic and comprehensive report on the chemical constituents and pharmacological effects of naphthoquinones. In this review, we summarized the chemical constituents of naphthoquinones with pharmacological activity, finding that R. nasutus and naphthoquinones have a great potential to be developed as a traditional Chinese medicine for tumors, diabetes, nonalcoholic fatty liver, which can provide an important scientific basis for defining the pharmacodynamic basis of the pharmacological activities and a reference for further research and comprehensive utilization of Zhuang medicine of Rhinacanthus nasutus.
