Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis
10.13422/j.cnki.syfjx.20201422
- VernacularTitle:当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床观察
- Author:
Wen LI
1
;
Xiao-yun DAI
1
;
Xin-qiao KE
1
Author Information
1. Shenzhen Longhua District Central Hospital, Shenzhen 518110, China
- Publication Type:Research Article
- Keywords:
Danggui Niantongtang;
Xuanbitang;
acute gouty arthritis;
damp-heat type;
inflammatory factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(14):117-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of modified Danggui Niantongtang combined with Xuanbitang in treating damp-heat type acute gouty arthritis, and investigate its effect on levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). Method:Totally 126 patients were randomly divided into control group and observation group, with 63 cases in each group. In addition to non-medication treatment, patients in control group were given conventional western medicine treatment for 1 week, while patients in observation group were given modified Danggui Niantongtang combined with Xuanbitang for 1 week. The levels of IL-1β，IL-6，IL-8，TNF-α before and after treatment were observed. Result:The total effective rate was 79.37% in control group and 95.24% in observation group, with significant differences (P<0.05). After treatment, the scores of arthralgia, tenderness, swelling, activity restriction in both groups were significantly decreased (P<0.01), and those in observation group were lower than those in control group (P<0.05). The levels of uric acid (UA), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) were significantly decreased (P<0.01) after treatment, and those in observation group were lower than those in the control group (P<0.05). The levels of IL-1β，IL-6，IL-8，TNF-α were significantly decreased (P<0.01) after treatment, and those in the observation group were lower than those in the control group (P<0.05). Conclusion:Compared with conventional western medicine treatment, modified Danggui Niantongtang combined with Xuanbitang has a better efficacy in treating damp-heat type acute gouty arthritis and reducing levels of IL-1β，IL-6，IL-8，TNF-α.
