Efficacy and Safety of Modified Chaihu Jia Longgu Muli Tang in Treating Mild to Moderate Essential Hypertension Complicated with Depression and Liver-Yang Hyperactivity Syndrome
10.13422/j.cnki.syfjx.202001390
- VernacularTitle:柴胡加龙骨牡蛎汤加味治疗轻中度原发性高血压合并抑郁肝阳上亢证的临床观察
- Author:
Yan-li TANG
1
;
Ji-ming WANG
1
;
Ting-yi ZHUANG
1
;
Cui YANG
1
;
Jin-ping FU
1
Author Information
1. Tianjin TEDA Hospital, Tianjin 300457, China
- Publication Type:Research Article
- Keywords:
modified Chaihu Jia Longgu Muli Tang;
hypertension;
depression;
liver-Yang hyperactivity syndrome;
endothelial-dependent vasodilation;
patient health questionnaire-9 score（PHQ-9）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(13):132-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and safety of modified Chaihu Jia Longgu Muli Tang in treating mild to moderate essential hypertension complicated with depression and liver-Yang hyperactivity syndrome.Method:Totally 121 mild to moderate hypertensive patients complicated with depression in line with the inclusive criteria were randomized into treatment group and control group. All of the enrolled patients in treatment group and control group were treated with conventional therapy. In treatment group, patients were given modified Chaihu Jia Longgu Muli Tang, one dose per day. The treatment course lasted for 4 weeks. Blood pressure, patient health questionnaire-9 (PHQ-9) score, score of traditional Chinese medicine syndrome, C-reactive protein (CRP), endothelial-dependent vasodilation, and adverse effect were observed in this study.Result:Both systolic blood pressure and diastolic blood pressure were significantly lowered when compared to control group (P<0.05). PHQ-9 score was significantly improved in treatment group (P<0.05). The score of traditional Chinese medicine syndrome was significantly improved in treatment group compared to control group (P<0.05). CRP was significantly improved in treatment group compared with control group (P<0.05). Endothelial-dependent vasodilation was significantly improved in treatment group compared with control group (P<0.05). No severe adverse effect was observed in this research.Conclusion:Chaihu Jia Longgu Muli Tang has a creation clinical efficacy in the treatment of mild to moderate essential hypertension with depression. In addition to the effect in reducing both systolic and diastolic blood pressure, modified Chaihu Jia Longgu Muli Tang was also effective in improving depression, traditional Chinese medicine syndrome and endothelial-dependent vasodilation, and reducing the level of CRP with little adverse effect.
