Investigation of Relationship Between Spleen and Alzheimer' s Disease Based on Glucose, Lipid and Energy Metabolisms
10.13422/j.cnki.syfjx.20192147
- VernacularTitle:基于糖代谢、脂代谢和能量代谢探讨脾脏与阿尔茨海默病的关系
- Author:
Qin ZHENG
1
;
Jun LUO
1
;
De-lin ZHANG
1
;
Yu TANG
1
;
Mei-fang ZHU
1
;
Dan-feng TANG
1
;
Hai-xia WU
1
;
Yuan-yuan GUO
1
Author Information
1. State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Key Laboratory of Modern Chinese Medicine Preparations, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
glucose metabolism;
lipid metabolism;
energy metabolism;
Alzheimer's disease;
spleen;
traditional Chinese medicine;
mitochondria
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(5):178-185
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer' s disease (AD) is a chronic neurodegenerative disease, which is seriously affecting people' s lives. Until now, the pathogenesis of AD is still unknown which result in its worldwide difficulties in prevention and treatment. Some studies have shown that AD might be a metabolic disease associated with glucose, lipid and energy metabolisms. Traditional Chinese medicine (TCM) believes that the spleen is acquired foundation and the origination of Qi and blood. The function of spleen is not only closely related to the metabolism of substance and energy, but also related to the aging of human body. In this article, we summarized and analyzed the interrelationship of metabolism, AD and spleen, as well as the effect of spleen-invigorating prescription on AD. The purpose of the paper is to analyze the possible mechanism of TCM treating AD from the perspective of regulating metabolism, explore the potential value of spleen-strengthening TCM in the treatment or prevention of AD, and provide new ideas for exploring the drug development and TCM therapy of AD.
