Tumor immunity and immunotherapy: opportunities and challenges
10.3872/j.issn.1007-385X.2021.01.001
- VernacularTitle:肿瘤免疫与免疫治疗：机遇与挑战
- Author:
GU Yan
1
;
CAO Xuetao
1
Author Information
1. National Key Laboratory of Immunology & Institute of Immunology, Naval Medical University, Shanghai 200433, China
- Publication Type:Journal Article
- Keywords:
tumor;
tumor immunity;
immunotherapy;
immune regulation;
tumor microenvironment;
immune checkpoint
- From:
Chinese Journal of Cancer Biotherapy
2021;28(1):1-10
- CountryChina
- Language:Chinese
-
Abstract:
With the development of new technology and the innovation of research mode, tumor immunological research has achieved rapid development, and tumor immunotherapy has also shown remarkable clinical efficacy, jointly promoting the improvement of tumor immunology from mechanism research to clinical transformation and from single discipline to multi-disciplinary integration. However, multiple challenges still exist in tumor immunological research, such as the animal model replication for clinical tumor study, the complexity of tumor intrinsic regulation and its relationship with host microenvironment, and the screening of immunotherapy targets and the prediction of treatment effect. These problems limit the further development and application of tumor immunology, but also bring research opportunities to basic and clinical immunology researchers. Therefore, this review summarizes the research status and challenges as well as looks into the future of tumor immunity and immunotherapy in five aspects: the change of research model,the innovation of mechanism, the exploration of research objects, the screening and evaluation of therapeutic targets, as well as the application and innovation of new technologies.
- Full text:20210101.pdf
