Progress of mesenchymal stem cells and exosomes derived from them in ovarian cancer
10.3760/cma.j.cn115355-20190828-00389
- VernacularTitle:间充质干细胞及其来源的外泌体在卵巢癌中的研究进展
- Author:
Ying LI
1
;
Zhongping CHENG
Author Information
1. 同济大学附属医院杨浦区中心医院妇产科，上海 200090
- From:
Cancer Research and Clinic
2020;32(5):367-369
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of ovarian cancer ranks the third among female malignancies. Mesenchymal stem cells (MSC) are an important part of the tumor microenvironment. Studies have shown that MSC can inhibit or promote the proliferation, invasion and metastasis of ovarian cancer cells by secreting various cytokines, promoting epithelial-mesenchymal transformation (EMT) and increasing the proportion of tumor stem cells. MSC can produce a large number of exosomes, and the exosomes derived from MSC have biological functions similar to MSC, which are important factors mediating the communication and transmission of information between cells. However, the effect of MSC-derived exosomes on tumors and its mechanism are still unclear. Therefore, the study of the mechanism of interaction between MSC and its exosomes in ovarian cancer may reveal a new approach to the treatment of ovarian cancer.
