Pay attention to the clinical application of immunoglobulin IgG subclass assay
10.3760/cma.j.cn114452-20200422-00417
- VernacularTitle:关注免疫球蛋白IgG亚类检测的临床应用
- Author:
Lieying FAN
1
Author Information
1. 同济大学附属东方医院检验科，上海 200120
- From:
Chinese Journal of Laboratory Medicine
2020;43(9):870-873
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin G (IgG) is the main immunoglobulin in human serum and can be divided into four subclasses of IgGl, IgG2, IgG3and IgG4, respectively. IgG mainly play protective roles in body immunity. The structures of IgG subclass are different, therefore, their functions ale also different in the occurrence of diseases. There is evidence that IgG subclass analysis has important clinical application value in the diagnosis, pathogenesis and prognosis of IgG4-related diseases, antibody deficiency and other diseases. Accelerating development and transformation of new technologies for IgG subclass detection, focusing on IgG subclass detection and clinical applications will be helpful to improve the ability to diagnose and treat the difficult and complex diseases.
