Clinical value of complements detection in C3 glomerulopathy
10.3760/cma.j.cn114452-20200212-00063
- VernacularTitle:补体检测在C3肾小球病诊治中的价值
- Author:
Yunfei DING
1
;
Feng YU
Author Information
1. 北京大学国际医院肾内科，北京 102206
- From:
Chinese Journal of Laboratory Medicine
2020;43(9):860-864
- CountryChina
- Language:Chinese
-
Abstract:
C3 glomerulopathy (C3G) is a rare type of kidney disease caused by dysregulated the activation of complement alternative pathway. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Immunofluorescence pathology of renal biopsy in C3G shows only C3 deposition or mainly C3 deposition. The pathogenesis of the disease has not been fully elucidated. Its clinical manifestations are diversified and there are some difficulties in its diagnosis and treatment. Given that the abnormal activation of the complement alternative pathway plays an important role in the occurrence and development of this disease, this article evaluates the clinical value of detecting complement components in C3G,providing clues for the diagnosis and treatment of C3Gpatients.
