Influence of antibody dependent enhancement (ADE) on vaccine development

VernacularTitle:抗体依赖性增强作用对疫苗研发的影响
Author: Weijin HUANG ¹ ; Youchun WANG
Author Information

1. 中国食品药品检定研究院，国家卫生健康委员会生物技术产品检定方法与标准化重点实验室，国家药品监督管理局生物制品质量研究与评价重点实验室，北京　102629
From: Chinese Journal of Microbiology and Immunology 2020;40(7):558-562
CountryChina
Language:Chinese
Abstract: Antibody dependent enhancement (ADE) is a common phenomenon in virology. It is involved in the mechanisms of infections caused by Dengue virus (DV), severe acute respiratory syndrome coronavirus (SARS-CoV), influenza virus, HIV and other viruses and affects the research and development of vaccines against them. Because the pre-existing specific antibodies or antibodies at sub-neutralizing titer can enhance the infectivity of viruses, leading to disease aggravation, vaccination may promote infection instead of preventing it. This article focused on the impact of ADE on the research and development of vaccines and the assessment of ADE.