Incidence of acute kidney injury within 3 days after lung transplantation, related risk factors and its influences on short-term prognosis
10.3760/cma.j.cn421203-20190213-00026
- VernacularTitle:肺移植术后三天内急性肾损伤的发生率和危险因素及其对短期预后的影响
- Author:
Shuai ZHANG
1
;
Min LI
;
Jingqing XU
;
Qingyuan ZHAN
Author Information
1. 中国医学科学院呼吸病学研究院 国家呼吸疾病临床研究中心 中日友好医院呼吸中心 呼吸与危重症医学科，北京 100029
- From:
Chinese Journal of Organ Transplantation
2020;41(6):328-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the incidence and relevant risk factors of acute kidney injury (AKI)after lung transplantation(LT).Methods:Retrospective analysis was performed for clinical data of 70 recipients of LT at China-Japan Friendship Hospital.Results:Among them, 61.4 % developed AKI within 3 days post-LT. As compared with non-AKI and AKI 1 groups, AKI 2~3 group had more plasma transfusion(median 0, 0, 200 ml, P=0.027) and more cardiovascular events during operation(0, 0, 14.3 %, P=0.023). As compared with non-AKI group, AKI 1 and 2~3 groups had lower postoperative hemoglobin in the first day(median 119, 106, 104 g/L, P=0.032). The duration of invasive mechanical ventilation was longer in AKI 2~3 group(median 56 h)than non-AKI group (median 49 h, P=0.034). The 3-month all-cause mortality post-LT was higher in AKI 2~3 (24.1 %)and AKI 1 recipients(21.4 %)than that in non-AKI counterparts(0)( P=0.034, P=0.007). Conclusions:Recipients with more blood transfusion and cardiovascular events during operation and those with more severe anemia in the first day post-LT might be at higher risks for postoperative AKI. Postoperative AKI prolongs the duration of invasive mechanical ventilation and increases 3-month all-cause mortality post-LT.
