Two cases of familial benign pemphigus treated with botulinum toxin type A
10.35541/cjd.20190525
- VernacularTitle:A型肉毒毒素治疗家族性良性天疱疮二例
- Author:
Jia TANG
1
;
Ying SHI
;
Junfeng ZHOU
;
Yao CHEN
;
Shanshan LI
Author Information
1. 吉林大学第一医院皮肤科，长春 130021
- From:
Chinese Journal of Dermatology
2020;53(5):368-370
- CountryChina
- Language:Chinese
-
Abstract:
Botulinum toxin type A was firstly used to treat two patients with familial benign pemphigus, who showed poor response to conventional therapies. Case 1, a 64-year-old male patient, presented with erythema and erosions on bilateral axillary and inguinal regions for 2 years, and was injected with botulinum toxin type A at a dose of 50 U in the right axillary fossa and right groin separately. Case 2, a 33-year-old female patient, presented with erythema and blisters on bilateral axillary and inguinal regions and the right waist for 9 years, and was injected with botulinum toxin type A at a dose of 25 U in the left axillary fossa, right waist and bilateral groins separately. After the injection of botulinum toxin type A, sweating was inhibited in the 2 patients within 1 week, and skin lesions were gradually attenuated within 2 weeks. One month after the injection, erythema and erosions on bilateral axillary and inguinal regions mostly regressed in the case 1, and no recurrence was observed during 18-month follow-up. Six weeks after the injection, most of the skin lesions regressed in the case 2, only patchy hyperpigmentation was observed, and no obvious new lesions occurred. A few lesions recurred in the case 2 during 10-month follow-up, but were attenuated after the treatment with topical glucocorticoids.
