Advances in the application of Mendelian randomization in investigating the etiologies of common diseases in the elderly
10.3760/cma.j.issn.0254-9026.2020.03.024
- VernacularTitle:孟德尔随机化法在常见老年病病因探索中的应用进展
- Author:
Ying ZHANG
1
;
Chen CHEN
;
Ruiyue YANG
;
Qi ZHOU
;
Xianghui LI
;
Ze YANG
;
Liang SUN
Author Information
1. 北京医院 国家老年医学中心 卫健委老年医学重点实验室 100730；北京大学第五临床医学院 100730
- From:
Chinese Journal of Geriatrics
2020;39(3):352-356
- CountryChina
- Language:Chinese
-
Abstract:
Mendelian randomization is a genetic epidemiological method for confounding adjustment of cross-sectional data by introducing genotypes as instrumental variables of exposure factors and possesses unique advantages for the adjustment of unmeasured and unknown confounding factors.In recent years, Mendelian randomization has been widely used and achieved rapid progress in the etiology research of common diseases in the elderly.This article reviews this method and its application in these diseases, including cardiovascular disease, type 2 diabetes mellitus, osteoporosis, Alzheimer's disease and malignant tumor.
