Clinical comparison between ductal carcinoma in situ and ductal carcinoma in situ with microinvasion
10.3760/cma.j.issn.1004-4221.2020.03.007
- VernacularTitle:乳腺导管原位癌与导管原位癌伴微浸润的临床比较
- Author:
Weixin LIU
1
;
Shulian WANG
;
Yu TANG
;
Hao JING
;
Jianyang WANG
;
Jianghu ZHANG
;
Jing JIN
;
Yongwen SONG
;
Weihu WANG
;
Yueping LIU
;
Hui FANG
;
Hua REN
;
Shunan QI
;
Ningning LU
;
Yuan TANG
;
Ning LI
;
Yexiong LI
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021
- Keywords:
Breast ductal carcinoma in situ;
Breast ductal carcinoma in situ with microinvasion;
Breast neoplasm/radiotherapy;
Breast neoplasm/surgery;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2020;29(3):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the differences in the treatment patterns,clinical characteristics,treatment outcomes and prognostic factors between breast cancer patients with ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with microinvasion (DCIS-MI).Methods Clinical data of 866 female patients including 631 DCIS cases and 235 DCIS-MI cases treated in our institution between 1999 and 2013 were retrospectively analyzed.The local control (LC),disease-free survival (DFS) and overall survival (OS) rates were calculated by Kaplan-Meier survival analysis.The prognostic factors were identified by Log-rank test.Results Similar LC,DFS and OS rates were obtained between two groups (all P＞ O.05).The univariate analysis demonstrated that Her-2-positive patients had worse OS and DFS than Her-2-negative counterparts.Patients undergoing breast-conserving surgery without radiotherapy had lower LC and DFS rates compared with those receiving radical mastectomy.Conclusions DCIS and DCIS-MI patients have similar clinical prognosis in terms of OS,LC and DFS.Her-2 positive is an unfavorable prognostic factor for DFS and OS.The LC and DFS rates in the breast-conserving surgery alone group are worse than those in the mastectomy group.
