Effect of metformin on serum thyrotropin in type 2 diabetes patients with euthyroidism
10.3760/cma.j.cn121361-20200122-00040
- VernacularTitle:二甲双胍对甲状腺功能正常的2型糖尿病患者血清促甲状腺激素水平的影响
- Author:
Lijuan YANG
1
;
Jing CHEN
;
Hong TAO
Author Information
1. 首都医科大学附属北京安贞医院内分泌代谢科 100029
- From:
Clinical Medicine of China
2020;36(6):481-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of metformin on serum thyrotropin (TSH) levels in type 2 diabetes patients with euthyroidism.Methods:A retrospective case-control study was conducted to analyze the clinical data of 180 patients with type 2 diabetes who were newly diagnosed with normal thyroid function or first treated with metformin from June 2014 to June 2018 in the endocrine metabolism Department of Beijing Anzhen Hospital Affiliated to Capital Medical University.The patients were divided into metformin group and non metformin group according to the different treatment plan, 90 cases in each group.According to the baseline TSH level, the metformin group was divided into 36 cases of high TSH (baseline TSH>2.50 mU/L-≤4.91 mU/L) and 54 cases of low TSH (baseline TSH ≥ 0.49 mU/L-≤ 2.50 mU/L). The high TSH group was further grouped and analyzed according to the level of thyroid peroxidase antibody (TPOAb). Treatment for 12 months.The changes of TSH, FT3 and FT4 were observed at baseline and 12 months after treatment.Results:There was no significant difference in serum TSH and thyroid hormone between metformin group and non metformin group at baseline and 12 months after treatment (all P>0.05). However, in metformin group subjects only with high-normal basal TSH level, significant decrease in TSH levels after 12-month therapy was observed ((2.31±1.48) mU/L vs.(3.19±0.62) mU/L, t=3.291, P=0.002). Further grouping analysis showed that, regardless of TPOAb positive / negative, the TSH level in the high TSH subgroup decreased significantly after treatment compared with that before treatment ( TPOAb(+ ): (1.92±1.27) mU/L vs.(3.34±0.56) mU/L, t=3.235, P=0.005) ( TPOAb(-): ( 2.36±1.50) mU/L vs.(3.16±0.63) mU/L, t=2.507, P=0.016). Conclusion:Metformin treatment reduced TSH levels in type 2 diabetic patients with normal and high baseline TSH, and TPOAb levels had no effect on this effect.
