Research progress of regulatory T cells in preeclampsia
10.3760/cma.j.cn431274-20200313-00283
- VernacularTitle:调节性T细胞在子痫前期中的研究进展
- Author:
Jiying CHEN
1
;
Chenhong WANG
Author Information
1. 深圳市龙华区中心医院妇产科 518110
- From:
Journal of Chinese Physician
2020;22(4):638-641
- CountryChina
- Language:Chinese
-
Abstract:
Preeclampsia (PE) is characterized by hypertension and proteinuria. Despite extensive research, the etiology and pathogenesis of PE are not completely understood. Increasing evidence suggests that an exaggerated maternal systemic inflammatofrery response may play a central role in the pathogenesis of preeclampsia (PE). Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act as potent suppressors of inflammation to prevent autoimmunity and graft rejection. A reduction in maternal Treg populations could prevent immunological tolerance of the fetus and has been associated with obstetrical complications, such as miscarriage, PE. The research of Treg in immunology is the focus of current research. In this paper, the relationship between the occurrence and development of regulatory Treg in preeclampsia is reviewed.
