Impacts of titanium-clip on inflammation and stress of patients with ulcer bleeding
10.3760/cma.j.cn431274-20191021-01205
- VernacularTitle:金属钛夹对消化道溃疡出血患者炎症及应激的影响
- Author:
Dan ZHOU
1
;
Xiaojiang XU
;
Wenwen ZHANG
;
Zhiping WU
;
Liula WU
Author Information
1. 广东医科大学附属第二医院消化内科，湛江 524003
- From:
Journal of Chinese Physician
2020;22(4):514-516,520
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the curative effect of titanium-clip combined with mucosal injection for peptic ulcer bleeding and the impact on inflammation and stress.Methods:126 patients were randomly divided into the control group and the observation group according to the method of random number table, 63 cases in each group. The control group received endoscopic mucosal injection of adrenaline, and the study group received titanium-clip additionally. The blood loss, amount of blood transfusion and hospital stay, the levels of inflammatory cytokines [C-reactive protein (CRP), interleukin (IL)-6 and IL-8] and stress indexes (blood sugar, adrenaline, cortisol and C-peptide) were compared between the two groups.Results:Compared with the control group, the blood loss, amount of blood transfusion and hospital stay in the observation group were significantly less ( P<0.05), and the contents of CRP, IL-6, IL-8, blood glucose, adrenaline, cortisol and C-peptide were significantly reduced at 12 hours after operation ( P<0.05). Conclusions:The joint application of titanium-clip and mucosal injection shows fewer impacts on inflammation and stress, and is safe for peptic ulcer bleeding.
