Bipolar disorder and gut microbiota
10.3760/cma.j.cn371468-20200228-01072
- VernacularTitle:双相情感障碍与肠道菌群
- Author:
Zhenzhu CHEN
1
;
Yan REN
;
Hong YANG
Author Information
1. 山西医科大学附属白求恩医院精神卫生科，太原 030000
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(5):475-480
- CountryChina
- Language:Chinese
-
Abstract:
Bipolar disorder is a chronic and severe mental disease, but its pathogenesis is still unknown.The disease is easy to relapse, and the cure rate is not ideal. The intestinal flora plays an important role in maintaining human health and regulating human function. The change of intestinal flora in human can directly or indirectly lead to the occurrence of a variety of diseases. And more and more studies have found that the intestinal flora of patients with many kinds of mental diseases and some of patients with physical diseases has obvious changes. Therefore, the in-depth study of brain-gut-flora axis has become a hot direction to explore the objective markers and pathogenesis of mental diseases. In this paper, the research progress of the relationship between intestinal microflora and bipolar disorder in recent years is reviewed. The changes of intestinal microflora in brain-gut-flora axis, bipolar disorder, the possible biological mechanism of bipolar disorder caused by intestinal microflora and the new discovery of treatment of bipolar disorder are discussed, which provides reference for further research and effective diagnosis and treatment of bipolar disorder biomarkers.
