Research progress on polarization regulation mechanism of alveolar macrophages in acute lung injury
10.3760/cma.j.cn121430-20200426-00335
- VernacularTitle:急性肺损伤中肺泡巨噬细胞极化调控机制的研究进展
- Author:
Sheng WANG
1
;
Li ZHENG
;
Xin LYU
Author Information
1. 同济大学附属上海市肺科医院麻醉科，上海 200433
- From:
Chinese Critical Care Medicine
2020;32(10):1269-1272
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury (ALI) is a common clinical critical disease, with a high mortality. The imbalance of alveolar macrophage (AMs) polarization plays an important role in the occurrence and development of ALI inflammation. The study of the regulation mode and mechanism of macrophage polarization can provide more theoretical basis for clinical prevention and treatment of ALI. In recent years, it has been found that epigenetics and immune metabolic microenvironment can affect the macrophage polarization and the immune inflammatory response of ALI. In this review, the progress of macrophage polarization, epigenetics and immune metabolism regulating macrophage polarization, the relationship between macrophage polarization and ALI were summarized, so as to clarify the effect and significance of regulating macrophage polarization on ALI, and provide new ideas for the prevention and treatment of ALI in clinic.
