Progress of nucleic acid as biomarkers on the prognostic evaluation of sepsis
10.3760/cma.j.cn121430-20200512-00378
- VernacularTitle:核酸水平在脓毒症预后评估中的价值研究进展
- Author:
Xiao XU
1
;
Wei XU
Author Information
1. 中国医科大学附属盛京医院儿童重症监护室，沈阳 110000
- From:
Chinese Critical Care Medicine
2020;32(7):880-884
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a refractory critical illness caused by infection. Clinicians use relevant biological indicators, combined with the physiological status and personal experience of sepsis patients to monitor the condition and assess the prognosis, which helps in preventing the development of the condition and reduce the mortality. New guidelines for the diagnosis and treatment of sepsis continue to emerge for early diagnosis and timely treatment and improve patient prognosis. However, it is still difficult to identify severe patients at an early stage and predict prognosis. At present, a series of basic and clinical studies on sepsis biomarkers are emerging, but no marker can achieve 100% sensitivity and specificity at the same time. In recent years, the use of nucleic acids to assess the condition of patients with sepsis and predict the prognosis has received increasing attention from researchers. This article reviews the role of cell-free DNA (cf-DNA), plasma mitochondrial DNA (mtDNA), microRNA (miRNA), and long-chain noncoding RNA (lncRNA) in the pathological process of sepsis and its relationship with prognosis, with a view of providing a deeper understanding of the mechanism of sepsis occurrence and development, as well as finding new markers for evaluating the condition and prognosis of sepsis.
