Serum IL-32 level in children with bacterial pneumonia and its relationship with disease severity
10.3760/cma.j.issn.1008-6706.2020.22.013
- VernacularTitle:细菌性肺炎患儿血清白细胞介素32水平与疾病严重程度的关系
- Author:
Yehua WANG
1
;
Dejun LI
;
Hongqin DU
Author Information
1. 浙江省，台州市肿瘤医院儿科 317502
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(22):2745-2748
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum interleukin-32(IL-32) level in children with bacterial pneumonia and its relationship with the severity of the disease.Methods:From January 2019 to December 2019, 300 children with bacterial pneumonia in Taizhou Cancer Hospital were selected as the pneumonia group, and 300 healthy children in our hospital were selected as control group.The serum levels of IL-32, IL-6, IL-8 and tumor necrosis factor-α(TNF-α) were measured by double antibody sandwich enzyme-linked immunosorbent assay.Results:The serum levels of IL-32[(212.46±16.74)ng/L], IL-6[(0.29±0.06)μg/L], IL-8[(0.41±0.08)μg/L] and TNF-α[(1.15±0.11)μg/L] in the pneumonia group were higher than those in the control group[(116.51±14.52)ng/L, (0.07±0.02)μg/L, (0.09±0.03)μg/L, (0.14±0.03)μg/L](all P<0.05). The serum levels of IL-32[(128.76±15.42)ng/L], IL-6[(0.15±0.04)μg/L], IL-8[(0.16±0.05)μg/L] and TNF-α[(0.29±0.06)μg/L] in children with pneumonia during recovery were lower than those in early stage[(212.46±16.74)ng/L, (0.29±0.06)μg/L, (0.41±0.08)μg/L, (1.15±0.11)μg/L](all P<0.05). The levels of serum IL-32[(232.16±16.02)ng/L], IL-6[(0.37±0.08)μg/L], IL-8[(0.54±0.09)μg/L], TNF-α[(1.42±0.15)μg/L] in the severe pneumonia group were higher than those in the non-severe pneumonia group[(184.26±16.31)ng/L, (0.23±0.05)μg/L, (0.26±0.06)μg/L, (0.79±0.12)μg/L](all P<0.05). There were positive correlation between serum IL-32 level and IL-6( r=0.602), IL-8( r=0.624), TNF-α( r=0.593) levels in children with pneumonia(all P<0.05). Conclusion:The serum IL-32 level is elevated in children with bacterial pneumonia.The serum IL-32 level can reflect the therapeutic effect, severity and inflammatory response of children with bacterial pneumonia.
