CT angiography combined with interventional therapy for diabetic foot and its effect on oxidative stress markers
10.3760/cma.j.issn.1008-6706.2020.17.019
- VernacularTitle:CT血管成像技术结合介入术治疗糖尿病足的效果观察及对氧化应激反应的影响
- Author:
Fushan LIU
1
Author Information
1. 山东省新汶矿业集团有限责任公司中心医院影像科，新泰 271219
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(17):2135-2139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of CT angiography combined with interventional therapy in the treatment of diabetic foot.Methods:A total of 80 patients with diabetic foot who were treated at the Central Hospital of Shandong Xinwen Mining Group Co., Ltd.from December 2017 to June 2019 were selected in the study.The patients were divided into two groups according to random double-blind method, with 40 cases in each group.The control group received open surgery, and the observation group received CT angiography combined with interventional surgery.The oxidative stress reactions[superoxide dismutase (SOD), nitric oxide (NO), lipid peroxide (MDA), nitric oxide synthase activity (iNOS)]before and after surgery, and postoperative complications were compared between the two groups.Results:The success rate of surgical treatment in the observation group was 100.0%, which in the control group was 95.0%, the difference was not statistically significant(χ 2=0.513, P=0.474). The operation time[(28.49±3.64)min], intraoperative blood loss[(2.13±0.47)mL], limb activity time[(1.24±0.51)d], hospital stay[(2.17±0.24)d]in the observation group were lower than those in the control group[(52.47±5.18)min, (57.42±6.87)mL, (2.86±0.63)d, (6.45±0.52)d], the differences were statistically significant( t=23.955, 50.782, 25.349, 47.265, all P<0.05). The incidence of postoperative complications in the observation group was 5.00%, which was lower than that in the control group(27.50%), the difference was statistically significant(χ 2=5.878, P=0.015). At postoperative 7d, the levels of SOD, NO, iNOS and MDA in the observation group were (354.26±21.83)U/L, (41.95±6.43)μmol/L, (77.12±1.86)U/L, (11.68±2.59)nmol/L, respectively, which in the control group were (355.11±32.78)U/L, (42.05±8.42)μmol/L, (78.22±1.85)U/L, (11.55±2.45)nmol/L, respectively, the differences were no statistically significant between the two groups (all P>0.05). Conclusion:CT angiography combined with interventional therapy in the treatment of patients with diabetic foot has high success rate of surgery, which can reduce the incidence of postoperative complications, and promote recovery of patients after surgery.However, CT angiography combined with intervention will increase the oxidative stress response of patients after surgery.Therefore, anti-oxidative stress drugs should be used to improve the prognosis of patients and improve the effect of interventional therapy.
