Effect of Chaiqinchengqi decoction combined with esomeprazole on cytokines and intestinal mucosal barrier function in patients with severe acute pancreatitis
10.3760/cma.j.issn.1008-6706.2020.13.007
- VernacularTitle:柴芩承气汤联合埃索美拉唑对重症急性胰腺炎患者细胞炎性因子和肠道黏膜屏障功能的影响
- Author:
Minwei YANG
1
Author Information
1. 浙江省，诸暨市第三人民医院内一科 311825
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(13):1564-1568
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of Chaiqinchengqi decoction combined with esomeprazole on cytokines and intestinal mucosal barrier function in patients with severe acute pancreatitis.Methods:From January 2018 to September 2019, 62 patients with severe acute pancreatitis who were treated in the Third People's Hospital of Zhuji were selected, and they were randomly divided into control group and combined group according to the random number table method, with 31 cases in each group.The control group was treated with esomeprazole, while the combined group was treated with Chaiqinchengqi decoction on the basis of the control group.The treatment course of the two groups was 14 days.The therapeutic effect and the recovery of gastrointestinal function of the two groups were compared.The changes of inflammatory factors and intestinal mucosal barrier function were observed before and after 14 days of treatment.Results:The total effective rate of the combined group was 93.55%(29/31), which was higher than that of the control group[67.74%(21/31)], the difference was statistically significant(χ 2=6.613, P<0.05). The recovery time of abdominal distention[(2.61±0.32)d], abdominal pain[(4.78±1.24)d] and bowel sounds[(1.96±0.37)d] in the combined group were shorter than those in the control group[(5.23±1.21)d, (8.63±1.49)d and (4.12±1.17)d], the differences were statistically significant( t=11.655, 11.058, 9.801, all P<0.05). The serum levels of TNF-α[(29.74±6.13)ng/L], IL-6[(35.46±8.71)ng/L] and CRP[(62.13±10.48)mg/L] in the combined group were lower than those in the control group[(49.65±8.76)ng/L, (59.73±6.63)ng/L and (98.74±15.36)mg/L], the differences were statistically significant( t=10.368, 12.345, 10.962, all P<0.05). The levels of DAO[(1.72±0.62)ng/L], D-lactate[(7.85±1.43)mg/L] and endotoxin[(2.13±0.46)Iu/L] in the combined group were lower than those in the control group[(3.20±0.56)ng/L, (11.27±3.10)mg/L and (4.25±0.51)Iu/L], the differences were statistically significant ( t=9.863, 5.578, 17.186, all P<0.05). Conclusion:Chaiqinchengqi decoction combined with esomeprazole is effective in the treatment of severe acute pancreatitis, which can reduce the cellular inflammatory response and improve the intestinal mucosal barrier function.
