Progress in research of Müller cell reprogramming in retinal regeneration
10.3760/cma.j.cn115989-20200110-00019
- VernacularTitle:Müller细胞重编程参与视网膜再生研究进展
- Author:
Zhenzhen ZHAO
1
;
Jian LIANG
Author Information
1. 上海市第一人民医院 国家眼部疾病临床医学研究中心 上海市眼底病重点实验室 上海眼视觉与光医学工程技术研究中心 上海市眼科疾病精准诊疗工程技术研究中心 200080
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(10):885-889
- CountryChina
- Language:Chinese
-
Abstract:
Müller glia, the major type of glial cells in retina, is crucial for maintaining retinal homeostasis.Although Müller cells have the features to re-enter into the cell cycle and differentiate into neural cells for promoting retinal regeneration after retinal damage in zebrafish, these features are rigorously restricted in higher animals.It has been reported that the reprogramming of Müller cells cannot be activated spontaneously in higher animals, but the reprogramming ability and transdifferentiation to neuron can be achieved by induction.The neurogenic potential of mammalian Müller glia makes it promising in restoring retinal regeneration.In this article, we review the progresses of Müller glia-to-neuron transdifferentiation with respect of the origin, and summarize the pathophysiology characters of Müller glia, mechanisms of reprogramming, methods of inducing mammalian Müller glia to neuron and factors limiting Müller glia-to-neuron in higher animals.Besides, we propose the advantages as well as the current challenges of Müller glia-to-neuron transdifferentiation.
