Research progress of mild hypothermia combined with neuroprotective agents in the treatment of neonatal hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1673-4912.2020.08.014
- VernacularTitle:亚低温与神经保护剂联合治疗新生儿缺氧缺血性脑病的研究进展
- Author:
Zhiguang CHEN
1
;
Hongmin WU
Author Information
1. 中国医科大学附属第一医院新生儿病房，沈阳 110001
- From:
Chinese Pediatric Emergency Medicine
2020;27(8):627-630
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic-ischemic encephalopathy(HIE) is one of the critical diseases in neonatal ward, which can lead to neonatal death or serious neurological sequelae.Mild hypothermia treatment is currently accepted.Although it could reduce the mortality and the risk of neurological sequelae of neonates with moderate and severe HIE to a certain extent, there were still some children who died or left neurological dysfunction.Neuroprotective agents play an important role in anti-excitotoxicity, anti-oxidation, anti-inflammatory and anti-apoptosis.This review provided the research progress of the combination of mild hypothermia and neuroprotective agents in the treatment of neonatal HIE.
