Study insights into inflammatory bowel disease through pyroptosis
10.3760/cma.j.issn.1673-4912.2020.07.016
- VernacularTitle:细胞焦亡在炎症性肠病中的研究进展
- Author:
Lian JI
1
;
Xiaolin YE
Author Information
1. 中国医科大学附属盛京医院实验研究中心，辽宁省环境与代谢疾病动物模型研究与应用重点实验室，沈阳 110004
- From:
Chinese Pediatric Emergency Medicine
2020;27(7):550-553
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is characterized by chronic relapsing intestinal inflammation which caused by genetic and environmental factors.With the research on the pathogenesis of IBD, current studies show that pyroptosis may be involved in the development of IBD.As an essential part of programmed cell death, pyroptosis is an inflammatory response that is elicited upon infection by intracellular pathogens.Activated inflammatory caspases will induce pyroptosis.According to the role of Caspase in programmed cell death, it can be divided into Caspase-1-dependent canonical pathway and Caspase-4/5/11-dependent non-canonical pathway.Activated inflammatory caspases cleave the pore-forming effector protein, gasdermin-D, inducing osmotic pressure deregulation of internal fluids and subsequently rupturing the cell membranes.Pyroptosis may be a potential therapeutic target for IBD in the future.This review described the mechanism of pyroptosis and therapeutic strategies for IBD.
