An observational study of Dexibuprofen and Naproxen in the treatment of juvenile idiopathic arthritis in children
10.3760/cma.j.cn101070-20190802-00708
- VernacularTitle:右旋布洛芬和萘普生在治疗儿童幼年特发性关节炎中的对照观察
- Author:
Tong XIE
1
;
Wei YIN
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院风湿免疫科，武汉 430016
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(21):1656-1658
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of Dexibuprofen and Naproxen in the treatment of juvenile idiopathic arthritis.Methods:The data of children with juvenile idiopathic arthritis admitted to Wuhan Children′s Hospital, Tongji Medical College of Huazhong University of Science and Technology from March 2017 to June 2018 were retrospectively analyzed.According to the types of painkillers used, the children were divided into the Dexibuprofen group (observation group) and Naproxen group (control group). The observation group was given 7 mg/kg Dexibuprofen each time and twice one day, while the control group was given 5 mg/kg Naproxen each time and twice one day.Visual analogue scale (VAS) was used to evaluate the relief of joint pain and adverse drug reactions before and after medication in the 2 groups.Results:A total of 97 children were enrolled in this study, including 48 in the observation group and 49 in the control group.There were no significant differences in gender, age and the joint location between the 2 groups(all P>0.05). Doctors ( P=0.736), children and their families ( P=0.563) all agreed that there was no significant difference in the analgesic effect between the 2 groups, but the tolerance score of Dexibuprofen was higher that of Naproxen [doctors ( P=0.025), children and their families ( P=0.024)]. The incidence of gastrointestinal adverse reactions was 4.2% in the observation group (2 cases) and 18.4% in the control group (9 cases), and the difference between 2 groups was significant ( χ2=4.863, P=0.027). Conclusions:The analgesic effect of Dexibuprofen is same to that of Naproxen in the treatment of children with juvenile idiopathic arthritis, but Dexibuprofen has a better tolerance rate and causes less gastrointestinal adverse reactions.
